793
PŮVODNÍ4021200011151111173233294355388
PRÁCE4435200011151111174230285
/4746200011132
ORIGINAL4804200011158118151213244306367421
PAPER5250200011151107163217278
Porovnání6713200974386113157196241280325344
nefrakcionovaného10323200974586110138177215251270314360404443482527568614658
heparinu17073200974586132172198218263307
a203132009739
nízkomolekulárního2087320097446398136180248292312353392437456495522567586633677
heparinu27813200974586132172198218263307
v310532009739
tromboprofylaxi3161320097265397165211256302329374398439459498537556
kriticky3734320097386685112132168206247
nemocných39983200974485153197235279317352397
pacientů44123200974685122141182227253298
s472732009732
covid-1947763200973579117137183209246283
pneumonií…50763200974691132177244289334353373451
|5584190011126
95654190011145
/24948040010732
Anest25718040010752100145178207
intenziv279880400107196794136184221240282
Med.30998040010770115165181
2026;37(1):8-153299804001074487129171186230271291331348363407435474511
/38558040010732
ANESTEZIOLOGIE39528040010753112156200246291342362425468527586607651
A46248040010753
INTENZIVNÍ4699804001071978123168226276296344405425
MEDICÍNA51468040010770114173194248268327381
www.aimjournal.cz4258040010765133201214257275349367415463490539579598614654693
Comparison425520016682151260333399463505563632708
of1157520016668116
unfractionated1297520016677155205268334394448489557633700750815890
heparin2211520016677139212278342385464
and2699520016665145218
low‑molecular‑weight294152001664010720524335141845751958165769976582987196610291069113512141264
heparin4229520016677140213279343386465
for425660016648115177
thromboprophylaxis6266600166511291932623724445135866477167908669299681035110711501208
in1858660016640119
critically2001660016661123166217258318385427469533
ill255866001664083125
patients2707660016674139190231294370420478
with3209660016698141192270
covid-193503660016661129194238311350410478
pneumonia:4005660016674151213288400467543586653689
A425800016687
retrospective536800016661126178240310367441505566620661725788
cohort1348800016661129205272334389
study1761800016656108184257321
Objective:4251010012370129155207252289314365415438
Covid-198801010012158111158181238269314359
is1257101001212362
associated1336101001214887126181226249296329378435
with1788101001217497130185
a19901010012148
significantly2056101001213962118173195225251295343398430453500
increased2574101001212378123155204252291341398
risk299010100121325694141
of3148101001215584
macrovascular32501010012183131175207261308356395440494518565597
and38651010012148103159
microvascular40421010012183106150183237284332371415470493540573
thrombotic4632101001213388120174258314369402425469
complications,5119101001214598181237261284328377425115001213356111167206227
especially673115001215090146197243266314337360408
in1102115001212479
critically1202115001214577101134157202250274297344
ill156811500121234669
patients16591150012157105138161211267299340
with2020115001217497130185
a22271150012148
severe2296115001214090138187220270
form2587115001212984117201
of2809115001215584
the2914115001213389139
disease.3074115001215780119169218257307327
Antithrombotic34221150012162117149172205261293347431488544576599644
prophylaxis4087115001215790145202258304328376423447486
is4594115001212463
an46781150012148103
important48031150012123106163219252288336392424
part52481150012157106138174
of5444115001215484
treatment425129001213366115164196279330385418
and8651290012148103160
was10471290012174122161
being12301290012157108132187243
applied14951290012148105162186209259317
using1834129001215594117172228
different2084129001215780109142192225275331363
drugs2469129001215689144201240
and27311290012148103160
dosing29131290012156111151173229285
schemes3220129001213985140190274324364
during36061290012156111143167222278
the3906129001213389139
pandemic.40671290012157106161218268352375420441
Data45301290012167115147196
comparing4748129001214599182239288320344399455
various5225129001214897129153208263302
possibilities4251430012157113152191214271294318341374397447486
of938143001215584
antithrombotic10481430012149104136159192247280334418475531563586631
therapy1706143001213388138171220276323
in2055143001212479
these2160143001213389139178229
patients24151430012157106139162212267300340
is2782143001212362
lacking.2871143001212371116163188243299320
The32171430012150106157
primary3400143001215790114197245277328
endpoint37541430012150106162219275298354386
of4166143001215585
this4277143001213388111150
study4454143001214073128185233
was47131430012174122161
a49011430012148
retrospective4975143001213383116149204243299350396431454503552
assessment425157001214886125174213252334383438470
of912157001215483
ICU-free1012157001212482144177206239288338
days,13671570012156103148187208
hospital-free15921570012155109148203227259307330361391423473523
days,21321570012156103148187208
and23571570012148102158
bleeding2532157001215680130180236259313369
or2918157001215486
thrombotic3022157001213387119172255311366398421465
complications3504157001214497180235259281325373405428482537575
in4097157001212377
critically4191157001214577100132155199247269292339
ill454715700121234669
patients46331570012156104136159208263295334
with4985157001217396128183
covid-195185157001214497144167223254298343
pneumonia,4251710012157112162217299354409432480500
who9431710012173128183
initially1144171001212378100133156203227249296
received1458171001213282127176199247296352
higher1828171001215578133188238271
doses21161710012156111150200239
of2373171001215483
anticoagulation24741710012147102134157201255303359413436484516538593648
therapy3140171001213387137170218274320
either3478171001215073106160210243
using3738171001215594117171227
subcutaneous3982171001214094150195250282331386436491546585
(s.458417100121296687
c.)468417100121446592
application47941710012148104160184207251299332354409464
of5276171001215483
low5377171001212378150
molecular4251850012183139163213259313337385417
weight8641850012174123147203258290
heparin11771850012155106163211244267323
(LMWH)1522185001212874155239304332
or1876185001215588
continuous1986185001214498154186209264319374430469
intravenous2477185001212378111143192238287343398454493
(i.299218500121285171
v.)307618500121486591
infusion3190185001212378107163202225280336
of3548185001215584
unfractionated36541850012155110139173221266301325380435483516565622
heparin42981850012156106163212245268323
(UFH).4644185001212892140204231250
The49161850012149106156
secondary5094185001214090136190246302350383433
endpoint4251990012150106162219275298354386
was8321990012174122161
to1014199001213488
compare1123199001214598182239287320370
30-day15141990012151102136195243289
mortality.18241990012183139172207256280303336386402
Design:4252130012368120162188246303326
Retrospective7722130012154104138170225264321372417453476524573
cohort1366213001214599155210243279
study.1666213001213973128185232249
Setting:4252270012352104140177202259317340
Intensive786227001212479112161217256278327376
Care11832270012158107139189
Unit13932270012165120143176
(ICU)1590227001212851110173201
of1812227001215584
a19172270012149
university19872270012155110133182231264304327360410
hospital.24182270012155111150206230263312335356
Material4252410012382133167218253278328354
and7962410012350107164
methods:9772410012384136171227283341383406
A14002410012161
retrospective1478241001213282115147200239295345390425448495544
analysis20392410012148102150173220258281319
of2376241001215483
medical24762410012183133189212256304327
records2820241001213382127180213268307
of3144241001215483
critically3244241001214577100132155199247270293340
ill360124100121234669
patients36872410012156104136159208263295335
with4040241001217396128183
covid-194240241001214497144167223255299344
associated4601241001214886125179224247294326375431
pneumonia50502410012156111161215298352407430477
and4252550012148102157
acute599255001214791145177225
respiratory841255001213281119174197229276308360392442
failure129925500121297799122175207255
was15712550012173120158
performed.17462550012156106138169223255337386442463
Patients2225255001215399131153202256288327
were25692550012173121153202
admitted27872550012148103185207239274322378
to3182255001213285
the3284255001213387136
ICU3437255001212380143
from3596255001212962115197
1.3810255001215066
3.3893255001215069
202039792550012151100147196
to4192255001213385
31.4294255001215195111
3.4421255001215170
202245082550012151100147197
and47212550012148102157
received4895255001213281126173196243291347
higher5259255001215577132186235267
doses4252690012156112151201241
of687269001215584
anticoagulation7922690012148104136159204257306362417440488521544599655
using1468269001215594117172228
s.1717269001214061
c.1791269001214566
nadroparine18782690012156104161193248305354386410465515
or2414269001215588
i.2523269001212445
v.2580269001214864
infusion2666269001212378107163202225280336
of3023269001215584
UFH31282690012165114177
at3326269001214981
least3428269001212474122161195
from3645269001212962117200
the3867269001213388138
second4026269001214091136190246302
to4349269001213488
eighth4458269001215073129185217272
day47512690012157105150
of4923269001215484
admission.50282690012148105188211250289312367423444
Results:4252830012357109151207233268311334
A7772830012161
total856283001213387120169192
of1066283001215584
1531168283001215296145
patients13312830012157105138161211267299340
were16892830012173123156205
included1912283001212479124147202258309366
in2296283001212379
the2393283001213388138
analysis.25492830012148104152175222262285324345
Median29122830012181132189212260315
of3245283001215584
ICU-free3347283001212482146179209242292343
days37082830012156104150190
at3916283001214880
3040142830012151102
days41342830012157105150190
was43422830012173122161
154521283001215196
days46352830012156104150189
for4842283001213085118
LMWH49782830012147128211277
group5273283001215688143198255
and4252970012148102158
12600297001215194
days7112970012156104148187
for916297001212883115
UFH10482970012164112175
group1240297001215587141195251
(p1508297001212984
=16102970012159
0.1932).1686297001215170114159207255280298
Median20022970012179129186208255310
of2329297001215483
hospital-free24292970012155109148203226259307330361390423472522
days29692970012155103148186
at3173297001214779
6032702970012150102
days33892970012156103148187
and35932970012148102158
9037682970012151102
days38882970012155103147186
was40922970012173120159
5,54268297001215169121
days44072970012156103148187
for4611297001212983115
LMWH47432970012147127209274
group5034297001215687141196251
and53032970012147102158
054782970012151
days4253110012156104149188
pro631311001215689143
UFH7913110012165113176
group984311001215688142197253
(p1255311001212884
=13573110012159
0.5511),1434311001215171124171217258279297
2617493110012151100
days18663110012157104149189
and20723110012148103159
2322483110012151102
days23673110012157104149189
(p2573311001212884
=26753110012159
0.6590)2752311001215171122171219271297
respectively.3067311001213282121177227273308330378427451498514
The35983110012150106156
difference3771311001215679108140190223272327372420
in4209311001212378
incidence4304311001212478123146202252307351400
of4721311001215584
thromboembolic4822311001213388120174257313369419502558614637660704
complications425325001214598181238261284329377409432487542581
was10243250012173121160
not12023250012155110142
significant1362325001214062118173196225251295344399431
(1.96%181032500121297591140191269
in2097325001212378
LMWH21933250012147127210276
group2486325001215688143197254
and27583250012148103159
7.84%2935325001215161114167244
in3197325001212378
UFH32923250012165113176
group3486325001215688142197254
(p3758325001212884
=38603250012159
0.2732)).3937325001215171124172222270296321339
Minor42943250012180103158213246
bleeding4558325001215680130181238261316371
complications4947325001214598181238261284329377409432487542581
were4253390012174123156206
more6533390012183139172221
frequent897339001212962112169224275330363
in1282339001212378
LMWH13833390012147128211277
group1682339001215689143199255
(11.76%1960339001212874116132182229307
vs.2289339001214988109
0.98%,2421339001215171120172251273
p27163390012157
=27953390012160
0.0058).2877339001215272123176227277304322
Logistic32213390012148102159182221255278323
regression3566339001213383139172222261300323378434
model40223390012184139196246270
found4315339001212984139195251
no45883390012156111
significant4721339001214063119174197227253297346401434
effect5177339001215080113163208244
of5443339001215584
anticoagulation4253530012148103136159204257306362417440488521544599654
therapy1101353001213388138171220276323
on14453530012155110
30-day15773530012151102136195243289
mortality.18873530012183138171207256280303336386402
Conclusion:4253670012359115174219246303346372429487510
No9643670012166123
statistically1115367001214075124157181220255278324373397420468
significant1612367001214063120176200230256302351407440
difference2080367001215781111144195228279335381431
was25393670012175124163
found2731367001213085141197255
between30153670012157109143219270321378
both34213670012158114148203
groups3653367001215790145201258298
in3980367001212480
the4088367001213490141
incidence4258367001212379125148205256313358408
of4695367001215585
thromboembolic4809367001213389122177262319376427512569626650674719
complications,425381001214599182239263286331379412435490546585606
the1056381001213388139
number12203810012156111194251302334
of1580381001215584
ICU-free1690381001212382146178208242291342
days,20583810012156104150190211
the2294381001213389139
number24593810012155110193250301334
of2818381001215584
hospital-free29283810012155110149206230263312335367397430480531
days.34853810012156104150189211
Logistic37213810012147102158182221255278322
regression4069381001213382139172222261300323378434
model45283810012184139196247271
proved4824381001215790144192241298
no51483810012155110
effect5284381001215080112162208243
of425395001215584
anticoagulation5353950012148103136159203257306362416440488520543598654
type1215395001213383140192
on14323950012155111
30day15693950012151102159207253
mortality.18483950012183138171207256280302336385402
In2276395001212379
the2380395001213489139
LMWH25453950012147128212277
group,2848395001215688143198255274
a31483950012148
higher3222395001215579134190240273
frequency3521395001212962112169224275330375425
of3971395001215584
minor40813950012184107162217250
bleeding4357395001215781131182239262318374
complications4756395001214599183239263286331380412435490546585
was53673950012173122161
observed,4254090012155112151202235286335392413
while8594090012174130153176226
the1106409001213489139
frequency1266409001213063113170225275331376425
of1713409001215584
major18184090012183131155210243
bleeding2082409001215781131182240263318374
complications2477409001214599182239263286331380412435490546585
did3083409001215680136
not32404090012156111144
increase.3405409001212379124156206254293344364
Key4254260012358108158
words:6034260012375131167225267290
covid-19,915426001214599146170226258303348366
heparin,13024260012156106163212244268323344
pneumonia,16674260012157113163218302357412436483505
intensive2193426001212378111160216255278326375
care.2589426001214594126176196
Úvod4254780015378141206278
Pandemie425496001074586134184228302320364
onemocnění816496001074897141215264305354398446465
způsobená1307496001073687135168217267312361402
novým1735496001074897137181256
typem2017496001072871122167241
koronaviru2284496001073886113160209250290309336384
SARS­2695496001074294139182210
‑CoV-2425510001072781128172198236
(covid-19)687510001072361107148167216244283321343
zdůraznila1055510001073685132158200237286304323364
význam1444510001074084122171212286
adekvátní1755510001074190134172216257285333352
tromboprofylaxe.2132510001072854101175225274324351398422466486526566609624
Jde2781510001073180124
především425524001075076119169213254288306380
o8265240010748
kriticky89552400107386685113132173210253
nemocné,1170524001074892166214255304348362
u15545240010747
nichž1623524001074866107155191
jsou1836524001071952100148
mikrovaskulární2006524001077392130158205245287320357406425465492540559
a25865240010741
makrovaskulární26485240010774115153181228425538001074081113150197215255280328346
trombotické78753800107275399172220269295313353390432
komplikace1234538001073884157205224242279320360401
jednou1651538001071962111158205252
z19195380010736
příčin197053800107497594133150197
orgánové2183538001074773120160207255294336
dysfunkce,2535538001074887120145192239276315356370
což425552001074085120
vede560552001074183132175
k7505520010738
negativnímu803552001074891140180206224264312330402449
ovlivnění1267552001074787106123163211254301319
klinického160255200107375775122140179216258305352
výsledku.1970552001074082115133176225262309325
Hyperkoagulační2310552001075695145189214252298339387433452491531577595
stav425566001073463104144
je587566001072063
výsledkem669566001074184118137181231269312385
nejen1073566001074893111155203
komplexních1295566001073885160209229273312361380420468
interakcí178156600107196794136163205243282300
mezi21005660010774118155175
virem,229356600107416087130203219
imunitním2531566001071892139187206234282301375
systémem,425580001073475110139182256301375391
koagulační843580001073886128178226245286327375394
a12645800010741
fibrinolytickou133258000107244494121140189238258298330349390428476524
kaskádou1883580001073881115153195245294343
a22535800010741
cévním2320580001074184125174193267
endotelem2614580001074493143191219262425594001071964140
(imunotrombóza),592594001072443118166215265293321369444495545581625647661
ale1280594001074262107
také1414594001072870109153
dalšími1594594001075092111145164239258
faktory1879594001072467106137185213257
kriticky216359400107396787116136177216260
nemocných,2450594001074994169219261310349390439455
např.425608001074991142170181
imobilita,633608001071994144196216235254283326342
přítomnost100360800107517898127175251300350385415
invazivních1445608001071969109152190210253303322364413
vstupů,1885608001074277107156207256272
orgánová2185608001074977126168217267309351
podpora,25646080010750101152203254282325341
vazopresorická425622001074182119167217244287320369396415455493535
podpora982622001075099149199248275317
apod.1321622001074190139189205
[1–3].154862200109266911115617917266220010716
Antitrombotická17646220010752101128146174201248322372421448467507545588
profylaxe2374622001074976123147191211251291334
hrála2730622001074875116135176
během425636001074994141185258
pandemie699636001074990138187230303321365
důležitou1080636001074995114157194212240286334
roli143063600107267392110
v15576360010740
terapii161363600107287096137186205223
kriticky185263600107386685112131170208250
nemocných2118636001074892165213253301339378426
s25606360010733
covid-192609636001074086126145194221259297
pneumonií,425650001075098143191264313362380399414
nejčastěji865650001074893112152193226256298317335
v12276500010740
podobě1294650001074999149197247292
subkutánní1612650001073481131169218246287335384402
(s.204065000107245673
c.)213965000107415780
aplikace2245650001074191110129166209250292
nízkomolekulárních2563650001074967104143190264313425664001071962100147166205231279297337384
heparinů825664001074891140181207226273319
(LMWH)1160664001072463133205261284
nebo1460664001074892140189
kontinuální1665664001073784132158177224270310329376394
intravenózní207566400107196692118159198241288336370418437
(i.252866400107234157
v.)260166400107405173
infuze269066400107196689137173216
nefrakcionovaného425678001074891114140181218256274321368416455495542585632680
heparinu1120678001074891139180205224270317
(UFH).1452678001072478119173196208
Vzhledem1676678001074580128146189238281353
k20446780010738
minimálnímu2097678001077391137155227267285332349421468
množství25806780010773120167202236264307325
klinicky42569200107385978127146187225269
relevantních72069200107277191135177219267295344363404452
doporučení1199692001075099150199227276317360409428
v16546920010741
úvodu1722692001074890138189237
pandemie1986692001075092141191236310329374
bylo2387692001075090110159
u25736920010748
kriticky264869200107386787115134175214257
nemocných425706001074892165213254302340379427
také868706001072869106149
doporučováno1033706001074997146195222270310356396437485533
zvážení1582706001073680121157200248266
vyššího1864706001074184117150168217265
dávkování2146706001074889128166213253294342360
antikoagulační2523706001074088114133170217258307355425720001071960100148167
terapie61472000107287097139188207251
v8877200010741
profylaktické951720001074976123147191211251289320339379417460
indikaci1433720001071967116135173215256274
[4].17297200010926699318217200010716
Dosažení18597200010758107141183220262311329
a22117200010740
udržení2274720001074897123162205253271
potřebné2568720001074999126152195245293338
efektivní425734001074467111149179198239288307
hladiny748734001074867108157176224262
antikoagulační1027734001074088115134172219260310357376416457505523
terapie156773400107287096138187206250
např.1834734001074889138165175
cestou2026734001074082116145191239
s.2282734001073450
c.2349734001074056
aplikací2422734001074190110128166208248267
může27067340010773121157200
být425748001075089120
u5697480010748
takovéto641748001072870108155195238266313
skupiny978748001073471119169188236275
pacientů1277748001074991132150194242269317
náročné1618748001074889115162203251296
z19387480010736
důvodu1998748001074997138185235283
alterovaných230574800107416088130157204244285333372412460
farmakokinetických2789748001072366924257620010775116155203243264313358386405447485529570618
poměrů,10717620010750100175220247297312
např.1411762001074890140168179
přítomností161776200107507897126173249298347382411431
orgánových2075762001074876125166216265306350391440
dysfunkcí,2542762001074990125151201250288328348363
horší425776001074897123157176
podkožní617776001075099149187234270318337
absorpci,971776001074090123172198249290308324
většímu1311776001074184112146164238285
distribučnímu1613776001074967100129156175224273313361379453500
objemu2130776001074898117161234282
pro2428776001075077124
hydrofilní2568776001074987136162209233253271319337
léčiva3047482001071963104123164205
apod.3270482001074190140190206
[5,349348200109267088
6].359848200109467136684820010716
Následné3702482001075798131150194244292336
selhání405648200107347897145186234252
terapie432648200107287097139188207251
by4595482001075089
pak4702482001075091129
mělo48494820010774118137185
negativní5052482001074893143183210229270319338
vliv540848200107406079120
na3047496001074889
výsledky3156496001074084117136180230268311
pacientů3487496001074991132150194242269317
[7].38234960010926739939214960010716
Naše3187510001075798131175
práce3379510001074976118158201
je3596510001071963
retrospektivní367651000107266997124171204253298336367385426475494
analýzou4186510001074189130149189227274322
souboru4525510001073482130179228255304
pacientů4845510001075091132150194242269317
s51785100010734
covid-195228510001074087127146195223262300
asociovanou3047524001074173121162180227267308356403451
pneumonií,3514524001074997141188261309357375393408
kterým3938524001073868110136179252
byly4206524001075089108147
podávány4370524001074997147187226267315353
vyšší4739524001074083116149166
dávky4922524001074888127166208
antikoagulační51465240010741881141331702172583073543047538001071960100148167
terapie323053800107287197139188207251
v34985380010741
profylaktické3555538001075077124148192211252290321340380418461
indikaci4032538001071967116135173215256274
buď4323538001075098148
ve4488538001074184
formě458953800107237198172216
s.4822538001073350
c.4889538001074056
aplikace4962538001074190110128166208249291
LMWH,52705380010740111184242257
anebo3047552001074189134184233
kontinuální3307552001073886135162181229276317337385403
i.3737552001071935
v.3798552001074153
infuze387855200107196790140177220
UFH.4124552001075799154171
Primárním432155200107467291165206233282301375
cílem472255200107405980124198
této494755200107287199146
studie5119552001073463111161180224
bylo5369552001075090110158
srovnání3047566001073358103142190229276293
počtu3356566001074896136165211
dnů3582566001074895141
strávených373856600107336186126165207253290329375
mimo4128566001077390162209
jednotku4352566001071961110156203229266313
intenzivní468056600107186590132178214232272319337
péče5032566001074992132173
(ICU‑free522056600107244191145173196223264307
days)3047580001074989127161182
do3245580001074997
30.3358580001074487102
dne3476580001074997141
hospitalizace,3633580001074896129178197225266284302339381421463477
počtu4126580001075099139169217
dnů4359580001074996143
strávených451958000107336288129169212259298337384
mimo4920580001077391164212
nemocnici5149580001074891165213254301320360378
(hospital‑free3047594001072473121154204223251292311339364391434479
days)3548594001074989128162183
do3753594001074997
60.3872594001074489104
a39985940010741
90.4061594001074489104
dne,4187594001074997142156
jakož436559400107196098145180
i45675940010719
počtu4608594001075099140170218
dokumentovaných4848594001074997136184258302350377423464505553592631679
krvácivých3047608001073867111153194213254298338386
a34606080010741
tromboembolických3528608001072855102177227277322396446496516535575613657697745
komplikací4300608001073886161211231249287330371390
v47166080010741
obou4784608001074899148197
skupinách5008608001073371120170189238279320368
během54036080010750953047622001074892166
sledovaného323862200107345397147195235277325369417466
období.3729622001074898148196247266282
Sekundárním4036622001074286124172220270310337386404478
cílem453962200107405980124197
bylo4761622001075090109157
porovnání4944622001074999126173213262303351369
jejich533962200107196381100140188
30denní3047636001074487138182230278297
mortality.33646360010773122149180221240258286329341
Soubor30476600015366133205273339399
a34696600015362
metoda355466000153102161214280352416
Byla3047678001074586105146
provedena3209678001075077124164207257301349389
retrospektivní361567800107266997123170204253298336366385426475493
analýza4125678001074189129148188227269
dat4410678001074990117
kriticky454367800107386685113132172210252
nemocných4812678001074892166214255303341381429
pacientů52576780010750911321501942423047692001072876
se3149692001073478
základní3254692001073679117138178228276295
diagnózou3575692001074968109158207255291338386
covid-193988692001074087127147196224263301
asociované4316692001074174123164183231271313361406
pneumonie,4748692001075099143191265314363381425440
přijatých521469200107507796115156183226265314
na3047706001074990
jednotku3164706001072065116165214242281330
intenzivní352170600107196896139188226246288338357
péče3905706001075096138181
(JIP)411370600107245776122145
Kliniky428570600107456685134153192236
anesteziologie,4548706001074190135170199243281301350370419470489534549
resuscitace5124706001072771105153187228247276318360403
a30477200010741
intenzivní311472000107196794137186223242283333352
medicíny34927200010774118169188228247295334
Fakultní3852720001074279117166185213262280
nemocnice4159720001074893167216257305324365407
Ostrava4593720001076095124151193232274
(FNO)4894720001072465121183205
v51257200010741
České5193720001075194128166209
republice54297200010726693047734001075098148167186226268
od3333734001074898
1.3449734001074355
3.3521734001074459
20203598734001074487128171
do3787734001074997
31.390273400107448294
3.4013734001074459
2022.4090734001074487128172188
Mezi42957340010770114152171
vstupní4484734001074074103151201249268
kritéria476973400107396786114156183202243
patřilo5029734001075091119145164183231
použití5278734001075099147184203231250
antikoagulační3047748001074189116135172220261311358377418458506525
terapie359874800107277096138188207251
alespoň3875748001074059103137186235284
od4185748001074898
druhého4309748001074975124172216264313
do4648748001074997
osmého4771748001074881155199247296
dne5093748001074997141
pobytu5260748001074999149188219267
na3047762001074889
JIP316276200107315095
buď3284762001074998148
ve3458762001074184
formě356876200107247198173217
kontinuální3811762001073885134161180227275316335382401
i.4238762001071935
v.4299762001074153
infuze437876200107196690139176219
UFH,4623762001075698153169
anebo4818762001074189133183232
s.5076762001073451
c.5153762001074056
aplikace5235762001074191110129167209249292
LMWH.30477760010740111184242258
První3327776001074571115164182
den3531776001074993141
terapie369477600107277097138188207251
nebyl3966776001074993142182202
sledován418977600107345396147195235277325
s45357760010734
ohledem4591776001074896115159209253327
na4940776001074889
úvodní5050776001074889137187235253
titraci532577600107284775102143184202